2,493 research outputs found
Septic Abortion Managed in a Tertiary Hospital in West Bengal
Background: Septic abortion is still a challenging problem and a major cause of maternal mortality and morbidity in developing countries.Aim: The present study was conducted to estimate incidence, causes, risk factors, associated microorganisms, and treatment modalities of cases of septic abortion managed in a tertiary health care in West Bengal.Subjects and Methods: It was a cross‑sectional study carried out in Burdwan Medical College and Hospital in West Bengal between July 2011 and June 2012. On admission a thorough history was taken, examination was done, and investigations were carried. Depending on the examination findings the cases were grouped into three grades‑grade I: The infection localized in the uterus; grade II: The infection spread beyond the uterus to the parametrium, tubes, and ovaries or pelvic peritoneum; grade III: Generalized peritonitis and/or endotoxic shock or jaundice or acute renal failure. Statistical analysis was done by using Epi Info™ software (Version 3.5.1, CDC) after proper arrangement of all the data in tabular form and presented as simple percentage.Results: During the period, 1297 cases of abortion were admitted among which 107 were septic abortions, thus giving the incidence of the latter as 8.2% (107/1297). Forty‑three percent cases of septic abortion (46/107) were in grade I, 21.5% (23/107) in grade II, and 35.5% (38/107) in grade III. The modal age group of the patients was 15‑25 years (49.5%). Majority of the subjects were married (77.6%; 83/107) and multiparous (60.7%; 65/107). Similarly, most of them (71%; 76/107) were from low socioeconomic class. Ninety percent of the patients (96/107) had induced abortion. The common clinical features at presentation were pallor (88.8%; 95/107) and fever (86.0%; 92/107). Escherichia coli (62.6%; 67/107) and Klebsiella pneumonia (32.75%; 35/107) were the most common organism isolated. The case fatality from septic abortion in this study was 13.1% and the condition accounted for 15.4% of total maternal mortality within the period reviewed.Conclusion: The incidence of septic abortion in this study is relatively high, and majority of the cases resulted from attempted termination of pregnancy. It is a significant contributor to maternal mortality. Promotion of family planning and legalization of abortion services will go a long way in reducing the incidence of septic abortion and itsassociated complications. Keywords: Asia, management, maternal mortality, outcome, septic abortio
Nonlinear Hydrodynamics from Flow of Retarded Green's Function
We study the radial flow of retarded Green's function of energy-momentum
tensor and -current of dual gauge theory in presence of generic higher
derivative terms in bulk Lagrangian. These are first order non-linear Riccati
equations. We solve these flow equations analytically and obtain second order
transport coefficients of boundary plasma. This way of computing transport
coefficients has an advantage over usual Kubo approach. The non-linear equation
turns out to be a linear first order equation when we study the Green's
function perturbatively in momentum. We consider several examples including
term and generic four derivative terms in bulk. We also study the flow
equations for -charged black holes and obtain exact expressions for second
order transport coefficients for dual plasma in presence of arbitrary chemical
potentials. Finally we obtain higher derivative corrections to second order
transport coefficients of boundary theory dual to five dimensional gauge
supergravity.Comment: Version 2, reference added, typos correcte
Cytochrome c Reduction by H2S Potentiates Sulfide Signaling.
This is the author accepted manuscript. The final version is available from American Chemical Society via the DOI in this record.Hydrogen sulfide (H2S) is an endogenously produced gas that is toxic at high concentrations. It is eliminated by a dedicated mitochondrial sulfide oxidation pathway, which connects to the electron transfer chain at the level of complex III. Direct reduction of cytochrome c (Cyt C) by H2S has been reported previously but not characterized. In this study, we demonstrate that reduction of ferric Cyt C by H2S exhibits hysteretic behavior, which suggests the involvement of reactive sulfur species in the reduction process and is consistent with a reaction stoichiometry of 1.5 mol of Cyt C reduced/mol of H2S oxidized. H2S increases O2 consumption by human cells (HT29 and HepG2) treated with the complex III inhibitor antimycin A, which is consistent with the entry of sulfide-derived electrons at the level of complex IV. Cyt C-dependent H2S oxidation stimulated protein persulfidation in vitro, while silencing of Cyt C expression decreased mitochondrial protein persulfidation in a cell culture. Cyt C released during apoptosis was correlated with persulfidation of procaspase 9 and with loss of its activity. These results reveal a potential role for the electron transfer chain in general, and Cyt C in particular, for potentiating sulfide-based signaling.This work was supported by the French State in the frame of the “Investments for the future” Programme IdEx Bordeaux, reference ANR-10-IDEX-03-02, and by an ATIP-AVENIR grant (to M.R.F.), the National Institutes of Health (GM112455 to R.B. and R01GM113030 to M.D.P.), the Medical Research Council, UK (MR/M022706/1 to M.W.), the National Science Foundation (DGE-1309047 to A.K.S.), and the Brian Ridge Scholarship (R.T.). The authors are grateful to M.-F. Giraud for the help with purification of mitochondria
Application of enoki mushroom (Flammulina velutipes) stem wastes as functional ingredients in goat meat nuggets.
Not AvailableThe impact of different amounts (2%, 4% and 6%) of enoki (Flammulina velutipes) mushroom stem waste (MSW) powder on the physicochemical quality, color and textural, oxidative stability, sensory attributes and shelf-life of goat meat nuggets was evaluated. These mushroom by-products (MSW powder) contained a good source of protein (13.5%), ash (8.2%), total phenolics content (6.3 mg GAE/g), and dietary fiber (32.3%) and also exhibited the potential to be strong antioxidants, due to their good metal chelating ability (41.3%), reducing power (60.1%), and free radical scavenging activity (84.2%). Mushroom stem waste improved (p 0.05) in expressible water and textural properties were observed among the formulations, but MSW powder improved the water holding capacity and slightly decreased the hardness. Further, the inclusion of MSW significantly (p < 0.05) improved the oxidative stability and shelf-life of treated nuggets by reducing lipid oxidation during the nine-day storage period. Again, the inclusion of MSW did not negatively affect the color and sensory attributes of treated meat nuggets. Overall, our results suggest that enoki mushroom stem waste (4%) can be used as a value-added functional ingredient to produce nutritionally improved and healthier meat products
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases
Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress-induced and aging-related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine-immune system, which explain their traditional use for the treatment of a wide range of conditions. They exhibit a biphasic dose-effect response: at low doses they function as mild stress-mimetics, which activate the adaptive stress-response signaling pathways to cope with severe stress. That is in line with their traditional use for preventing premature aging and to maintain good health and vitality. However, the potential of adaptogens remains poorly explored. Treatment of stress and aging-related diseases require novel approaches. Some combinations of adaptogenic plants provide unique effects due to their synergistic interactions in organisms not obtainable by any ingredient independently. Further progress in this field needs to focus on discovering new combinations of adaptogens based on traditional medical concepts. Robust and rigorous approaches including network pharmacology and systems pharmacology could help in analyzing potential synergistic effects and, more broadly, future uses of adaptogens. In conclusion, the evolution of the adaptogenic concept has led back to basics of TMS and a new level of understanding of holistic approach. It provides a rationale for their use in stress-induced and aging-related diseases
Spectroscopic investigation of quantum confinement effects in ion implanted silicon-on-sapphire films
Crystalline Silicon-on-Sapphire (SOS) films were implanted with boron (B)
and phosphorous (P) ions. Different samples, prepared by varying the ion
dose in the range to 5 x and ion energy in the range
150-350 keV, were investigated by the Raman spectroscopy, photoluminescence
(PL) spectroscopy and glancing angle x-ray diffraction (GAXRD). The Raman
results from dose dependent B implanted samples show red-shifted and
asymmetrically broadened Raman line-shape for B dose greater than
ions cm. The asymmetry and red shift in the Raman line-shape is
explained in terms of quantum confinement of phonons in silicon nanostructures
formed as a result of ion implantation. PL spectra shows size dependent visible
luminescence at 1.9 eV at room temperature, which confirms the presence
of silicon nanostructures. Raman studies on P implanted samples were also
done as a function of ion energy. The Raman results show an amorphous top SOS
surface for sample implanted with 150 keV P ions of dose 5 x ions
cm. The nanostructures are formed when the P energy is increased to
350 keV by keeping the ion dose fixed. The GAXRD results show consistency with
the Raman results.Comment: 9 Pages, 6 Figures and 1 Table, \LaTex format To appear in
SILICON(SPRINGER
black hole at N=2 supergravity
In this paper, we consider the charged non-extremal black hole at five
dimensional N = 2 supergravity. We study thermodynamics of AdS_{5} black hole
with three equal charges (q_{1} = q_{2} = q_{3} = q). We obtain Schrodinger
like equation and discuss the effective potential. Then, we consider the case
of the perturbed dilaton field background and find presence of odd coefficients
of the wave function. Also we find that the higher derivative corrections have
no effect on the first and second even coefficients of the wave function.Comment: 17 pages, 4 figures. Published versio
Hydrodynamics of R-charged D1-branes
We study the hydrodynamic properties of strongly coupled Yang-Mills
theory of the D1-brane at finite temperature and at a non-zero density of
R-charge in the framework of gauge/gravity duality. The gravity dual
description involves a charged black hole solution of an
Einstein-Maxwell-dilaton system in 3 dimensions which is obtained by a
consistent truncation of the spinning D1-brane in 10 dimensions. We evaluate
thermal and electrical conductivity as well as the bulk viscosity as a function
of the chemical potential conjugate to the R-charges of the D1-brane. We show
that the ratio of bulk viscosity to entropy density is independent of the
chemical potential and is equal to . The thermal conductivity and bulk
viscosity obey a relationship similar to the Wiedemann-Franz law. We show that
at the boundary of thermodynamic stability, the charge diffusion mode becomes
unstable and the transport coefficients exhibit critical behaviour. Our method
for evaluating the transport coefficients relies on expressing the second order
differential equations in terms of a first order equation which dictates the
radial evolution of the transport coefficient. The radial evolution equations
can be solved exactly for the transport coefficients of our interest. We
observe that transport coefficients of the D1-brane theory are related to that
of the M2-brane by an overall proportionality constant which sets the
dimensions.Comment: 57 pages, 12 figure
Hydrodynamics from charged black branes
We extend the recent work on fluid-gravity correspondence to charged
black-branes by determining the metric duals to arbitrary charged fluid
configuration up to second order in the boundary derivative expansion. We also
derive the energy-momentum tensor and the charge current for these
configurations up to second order in the boundary derivative expansion. We find
a new term in the charge current when there is a bulk Chern-Simons interaction
thus resolving an earlier discrepancy between thermodynamics of charged
rotating black holes and boundary hydrodynamics. We have also confirmed that
all our expressions are covariant under boundary Weyl-transformations as
expected.Comment: 0+ 31 Pages; v2: 0+33 pages, typos corrected and new sections (in
appendix) added; v3:published versio
Wilsonian Approach to Fluid/Gravity Duality
The problem of gravitational fluctuations confined inside a finite cutoff at
radius outside the horizon in a general class of black hole geometries
is considered. Consistent boundary conditions at both the cutoff surface and
the horizon are found and the resulting modes analyzed. For general cutoff
the dispersion relation is shown at long wavelengths to be that of a
linearized Navier-Stokes fluid living on the cutoff surface. A cutoff-dependent
line-integral formula for the diffusion constant is derived. The
dependence on is interpreted as renormalization group (RG) flow in the
fluid. Taking the cutoff to infinity in an asymptotically AdS context, the
formula for reproduces as a special case well-known results derived
using AdS/CFT. Taking the cutoff to the horizon, the effective speed of sound
goes to infinity, the fluid becomes incompressible and the Navier-Stokes
dispersion relation becomes exact. The resulting universal formula for the
diffusion constant reproduces old results from the membrane
paradigm. Hence the old membrane paradigm results and new AdS/CFT results are
related by RG flow. RG flow-invariance of the viscosity to entropy ratio is shown to follow from the first law of thermodynamics together with
isentropy of radial evolution in classical gravity. The ratio is expected to
run when quantum gravitational corrections are included.Comment: 34 pages, harvmac, clarified boundary conditio
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